Getting to the root - Eczema Research

Research into the treatment of eczema with Chinese Medicine

Chinese Herbal Medicine and effective and safe treatment of atopic dermatitis (eczema)

In this ground breaking review, Yan et al (2020) explore the vast number biological mechanisms displayed by Chinese Herbal Medicine in the safe and effective treatment atopic dermatitis, a condition which effects up to 25% of children and 2-3% of adults. What truly sets this research apart is the exploration of the varied mechanisms of action in different Chinese Herbal Formulae, supporting the individuation of treatment based up on the experience of the person.

Yan et al (2020) available here: https://www.sciencedirect.com/science/article/pii/S0753332220303346


Chinese Herbal Medicine a multiple mechanism model in the prevention of atopic dermatitis (eczema)

When researchers looked to define the active ingredient in a Chinese Herbal Formulae for childhood eczema in the 1990s, they sought one key mechanism. Sadly this lead to missed opportunities in helping children with severe skin conditions such as atopic dermatitis. What research is increasingly finding is that Chinese Herbal Formulae possess multiple mechanisms as stated by Man, Hu and Elias (2019) “AD preventive herbs improve stratum corneum function, AD severity score and scratching via divergent mechanisms including improving epidermal permeability barrier function, lowering IgE levels, inhibiting inflammatory cell infiltration, cytokine expression and immune defence depending on the type of herbal ingredients utilized”

The Chinese Medical model has long recognised the multitude of mechanisms of herbal formulae, observed and discussed in the context of a natural empiricism based upon knowable, clinically relevant signs and symptoms.

Man et al (2019) Herbal Medicines Prevent the Development of Atopic Dermatitis by Multiple Mechanisms

https://link.springer.com/content/pdf/10.1007/s11655-015-2438-1.pdf


Topical Chinese Herbal Medicine in the treatment of eczema

Chinese Herbal Medicine is subject to ongoing research and investigation into its safety and efficacy. Studies are frequently carried out to investigate specific formulae and their mechanisms of action. Although the one size fits all approach taken in research does not a match the diversity and complexity of a clinical practice based upon generations of natural empiricism, it provides a greater understanding which can be utilised in modern day practice.

In a randomised control trial researchers found that the a topical ointment made using indigo naturalis used over a six week period was both safe and effective in the treatment of mild to severe atopic eczema. Indigo naturalis can come from the Isatis tinctoria, commonly known as woad (Lin et al, 2020)

https://www.sciencedirect.com/science/article/abs/pii/S0378874119327898?via%3Dihub



Further recent research:

Huang et al (2019) Efficacy and safety of Run Zao Zhi Yang capsule on chronic eczema: a multiple-centre, randomized, double-blind, placebo-controlled clinical study.

https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1571267?casa_token=GD5rLWSh2mMAAAAA%3AUtYYbrPWSoQzt4LA9zXLIoYdLzOspMiJ0EyXFPACfstrSklCckNGqO2p9W1KAX0L16z7GrV_bSevug

Srivastava et al (2020) Effect of Traditional Chinese Medicine (TCM) in moderate-to-severe eczema in clinic and animal model: beyond corticosteroids.

https://www.jacionline.org/article/S0091-6749(19)31993-1/fulltext

Lee et al (2019) Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis Symptoms via Regulation of Inflammatory Mediators.

https://www.frontiersin.org/articles/10.3389/fphar.2019.00742/full

Ma et al (2020) Efficacy and safety of Qinzhuliangxue decoction for treating atopic eczema: a randomized controlled trial

https://pubmed.ncbi.nlm.nih.gov/32389012/

Zheng et al (2019) Yu-Ping-Feng-San ameliorates recurrent allergic inflammation of atopic dermatitis by repairing tight junction defects of the epithelial barrier

https://www.sciencedirect.com/science/article/abs/pii/S0944711318304677

Huang (2019) Can We Treat Atopic Dermatitis without using Corticosteroids?

https://innovationinfo.org/articles/JPI/JPI-116.pdf